Pemodelan Farmakofor untuk Identifikasi Inhibitor Heat Shock Proteins-90 (HSP-90)
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چکیده
منابع مشابه
The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.
The 90-kDa heat shock protein (hsp-90) is an abundant cytosolic protein believed to play a role in maintenance of protein trafficking and closely associated with several steroid hormone receptors. Incubation of highly purified hsp-90 with [gamma-32P]ATP results in its autophosphorylation on serine residues. There are several lines of evidence which suggest that this activity is due to a kinase ...
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Recent work on the heat-shock protein Hsp90 by Rutherford and Lindquist (1998) has been included among the pieces of evidence taken to show the essential role of developmental processes in evolution; Hsp90 acts as a buffer against phenotypic variation, allowing genotypic variation to build. When the buffering capacity of Hsp90 is altered (e.g., in nature, by mutation or environmental stress), t...
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ژورنال
عنوان ژورنال: Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)
سال: 2020
ISSN: 2442-8744,2442-7284
DOI: 10.22487/j24428744..v.i.15036